The rnu (Rowett Nude) and rnuN (nznu, New Zealand Nude) Rat: An Update
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Long-Term Safety of PEGylated Coagulation Factor VIII in the Immune-Deficient Rowett Nude Rat
Turoctocog alfa pegol (N8-GP) is a glycoPEGylated human recombinant factor VIII for the treatment of hemophilia A. The safety profile of rFVIII, and polyethylene glycols (PEG) technology, is well-established. Conducting long-term toxicity studies in animals using human proteins can be complicated by anti-drug antibody (ADA) development. To evaluate long-term safety of N8-GP, 26- and 52-week tox...
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ژورنال
عنوان ژورنال: ILAR Journal
سال: 1992
ISSN: 1084-2020
DOI: 10.1093/ilar.34.1-2.3